Pioneering advanced quantum imaging and sensing technologies to investigate the multi-scale dynamics driving cellular behaviour
Our Cell research theme focuses on unlocking the complexities of life’s fundamental unit: the cell. Living cells are dynamic active materials, where their mechanical properties emerge from a network of filaments and motor molecules. Key processes like cell signalling, volume regulation, and division arise from nanoscale interactions.
To investigate the multi-scale dynamics driving cellular behaviour, we are pioneering advanced quantum imaging and sensing technologies. These innovations promise rapid measurement speeds, nanoscale spatial resolution, and ultra-high sensitivity, enabling us to study cells while minimizing damage to delicate biological samples.
Quantum sensing techniques offer exceptional sensitivity, allowing for low-power measurements that reduce the risk of photodamage. By leveraging entangled photon pairs, we can capture fast dynamic processes, facilitating the exploration of molecular interactions within cells. Our aim is to integrate these capabilities with super-resolution microscopy, enhancing imaging techniques for deep tissue studies.
In addition, our research will utilise quantum microscopy to improve measurement precision and spatial resolution across a range of applications, all while protecting biological samples.
These quantum advancements will complement our established classical measurement techniques, such as Raman and Brillouin microscopies, as well as optical tweezers and local viscosity measurements. This multifaceted approach will enable us to investigate complex cellular phenomena, including liquid-liquid phase separation in biomolecular condensates, cell division, and dynamic processes across cellular membranes. Through this work, we aspire to gain deeper insights into the mechanisms that underpin cellular function and life itself.
Our Impact
Quantum Microscopy Breakthrough Could Help Detect Hidden Threats in Our Food and Bodies
What if we could see the invisible? For example, the tiny molecules that signal disease or contamination without harming the cells we’re measuring.
Centre researchers from The University of Queensland have developed a new quantum-enhanced approach to Raman microscopy that uses quantum light to fingerprint molecules in biological samples in greater detail with less damage. This breakthrough could transform how we detect disease, monitor food safety, and study living cells in real time.
The microscope uses a special form of light called squeezed light that allows scientists to gather more information while avoiding damage and disruption on delicate samples. This is a turning point for studying living cells, where traditional imaging methods can be too harsh or too slow to capture fast-moving processes.
The technology builds on QUBIC’s mission to develop quantum tools that reveal how life works at the smallest scales. It’s part of a broader effort to understand how cells function, adapt, and sometimes fail, all insights that are essential for tackling diseases and improving health.
By combining quantum technologies with microscopy, the team has opened a new window into the living world. This technical achievement is an exciting new way to explore life, protect health, and respond to challenges we can’t yet see.
Published paper: Fast biological imaging with quantum-enhanced Raman microscopy (2024)
Contact us
If you would like to work or study with us within this research theme, please contact Cell Theme Lead, Dr Elizabeth Hinde.